Is it possible or not?

In challan no. 281, at a time only one section can be used to pay TDS.

NO sir you can not use this type of challan system, as at NSDL your challan will be one having unique Challan Serial Number, with identicle num there can not be any other challan, parts of challan can not be there, hence you can use the whole challan for either of sections u want.