Delivery challan Tax invoice

Greeting For Day....

We sent some material to our customer on delivery challan two time in one month, That time no e way bill is required material amount in less than 50k & delivery was in same state.

Now we received Purchase order from our customer and after including Manpower amount purchase order value exceed 50k, 

My Question

1. Do we need make E-way bill against  purchase order ?

2.How do we invoice ?